Glutethimide - DrugBank
NameGlutethimideAccession NumberDB01437TypeSmall MoleculeGroupsApproved, IllicitDescriptionA hypnotic and sedative. Its use has been largely superseded by other drugs. [PubChem]
StructureDownload Synonyms2-Ethyl-2-phenylglutarimide
DoridenInternational/Other BrandsDoriden (U.S.V .) / Elrodorm / Glimid (Polfa Pabianice) / Glutethimid (Balkanpharma) / NoxyronCategories
UNIICAS number77-21-4WeightAverage: 217.2637 Monoisotopic: 217. Chemical FormulaC13H15NO2InChI KeyJMBQKKAJIKAWKF-UHFFFAOYSA-NInChIInChI=1S/C13H15NO2/c1-2-13(10-6-4-3-5-7-10)9-8-11(15)14-12(13)16/h3-7H,2,8-9H2,1H3,(H,14,15,16)IUPAC Name3-ethyl-3-phenylpiperidine-2,6-dioneSMILESCCC1(CCC(=O)NC1=O)C1=CC=CC=C1IndicationFor the treatment of insomnia.
Structured Indications Not AvailablePharmacodynamicsGlutethimide is a hypnotic sedative that was introduced in 1954 as a safe alternative to barbiturates to treat insomnia. Before long, however, it had become clear that glutethimide was just as likely to cause addiction and caused similarly severe withdrawal symptoms.
Mechanism of actionGlutethimide seems to be a GABA agonist which helps induced sedation. It also induces CYP 2D6. When taken with codeine, it enables the body to convert higher amounts of the codeine (higher than the average 5 - 10%) to morphine. The general sedative effect also adds to the power of the combination.
TargetActionsOrganismAagonistHumanApositive allosteric modulatorHumanAbsorptionVariable
Volume of distributionNot AvailableProtein bindingNot AvailableMetabolismHepatic. Glutethimide is almost completely metabolized.
Route of eliminationglutethimide is inactivated by conjugation and the metabolites are excreted in urine, only 2% of the parent substance is excreted in urine, up to 2% of the dose has been reported to be found in the faeces.
Half life10-12 hours
ClearanceNot AvailableToxicityIn adults, death has been reported after 5 g. The usual lethal dose is 10 to 20g, although survival after a dose of 28 g has been reported.
Affected organismsHumans and other mammalsPathwaysNot AvailablePharmacogenomic Effects/ADRs Not AvailableDrug Interactions InteractionDrug groupThe risk or severity of adverse effects can be increased when Glutethimide is combined with 7-Nitroindazole.ExperimentalThe metabolism of Acenocoumarol can be increased when combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Acepromazine.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Aceprometazine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Adipiplon.InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Agomelatine.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Alaproclate.ExperimentalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Alfaxalone.Vet ApprovedThe risk or severity of adverse effects can be increased when Alfentanil is combined with Glutethimide.Approved, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Allopregnanolone.InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Alphacetylmethadol.Experimental, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Alphaprodine.IllicitThe risk or severity of adverse effects can be increased when Alprazolam is combined with Glutethimide.Approved, Illicit, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Amisulpride.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Amitriptyline.ApprovedThe risk or severity of adverse effects can be increased when Amobarbital is combined with Glutethimide.Approved, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Amoxapine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Amperozide.ExperimentalThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Glutethimide.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Articaine.ApprovedThe risk or severity of adverse effects can be increased when Asenapine is combined with Glutethimide.ApprovedAzaperoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Azaperone.Vet ApprovedGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Baclofen.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Barbital.IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Benperidol.InvestigationalThe risk or severity of adverse effects can be increased when Benzocaine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Benzyl alcohol.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Brexpiprazole.ApprovedBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Bromazepam is combined with Glutethimide.Approved, IllicitBromisovalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Bromisoval.ExperimentalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Bromperidol.InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Brompheniramine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Brotizolam.Approved, WithdrawnThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Glutethimide.Approved, InvestigationalGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet ApprovedThe risk or severity of adverse effects can be increased when Buspirone is combined with Glutethimide.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Glutethimide.Approved, IllicitButacaineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Butacaine.Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Butalbital.Approved, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Butamben.ApprovedThe risk or severity of adverse effects can be increased when Butethal is combined with Glutethimide.Approved, IllicitThe risk or severity of adverse effects can be increased when Butorphanol is combined with Glutethimide.Approved, Illicit, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Canertinib.InvestigationalThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Glutethimide.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Carbinoxamine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Carfentanil.Illicit, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Carisoprodol.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Cetirizine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Chloral hydrate.Approved, Illicit, Vet ApprovedThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Glutethimide.Approved, IllicitThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Glutethimide.Approved, WithdrawnThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Chlorphenamine.ApprovedThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Glutethimide.Approved, WithdrawnThe risk or severity of adverse effects can be increased when Glutethimide is combined with Chlorzoxazone.ApprovedThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Citalopram.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clemastine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clidinium.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clobazam.Approved, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with clomethiazole.InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clomipramine.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clonazepam.Approved, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clonidine.ApprovedClopenthixolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clopenthixol.ExperimentalThe risk or severity of adverse effects can be increased when Clorazepate is combined with Glutethimide.Approved, IllicitClorindioneThe metabolism of Clorindione can be increased when combined with Glutethimide.ExperimentalClothiapineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clothiapine.ExperimentalThe risk or severity of adverse effects can be increased when Clozapine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Cocaine is combined with Glutethimide.Approved, IllicitThe risk or severity of adverse effects can be increased when Codeine is combined with Glutethimide.Approved, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Cyclizine.ApprovedThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Cyproheptadine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dantrolene.ApprovedThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dapoxetine.InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Deramciclane.InvestigationalThe risk or severity of adverse effects can be increased when Desflurane is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Desipramine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Desloratadine.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Desvenlafaxine.ApprovedDetomidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Detomidine.Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dexbrompheniramine.ApprovedThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dextromoramide.Experimental, IllicitThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Glutethimide.Approved, Illicit, WithdrawnThe risk or severity of adverse effects can be increased when Dezocine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Diazepam is combined with Glutethimide.Approved, Illicit, Vet ApprovedThe metabolism of Dicoumarol can be increased when combined with Glutethimide.ApprovedDiethyl etherThe risk or severity of adverse effects can be increased when Glutethimide is combined with Diethyl ether.ExperimentalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Difenoxin.Approved, IllicitThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Glutethimide.Approved, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dihydroetorphine.Experimental, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dihydromorphine.Experimental, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dimenhydrinate.ApprovedDiphenadioneThe metabolism of Diphenadione can be increased when combined with Glutethimide.ExperimentalThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Glutethimide.Approved, IllicitDixyrazineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Dixyrazine.ExperimentalDoramectinThe risk or severity of adverse effects can be increased when Glutethimide is combined with Doramectin.Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Doxepin.ApprovedDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, Vet ApprovedDPDPEThe risk or severity of adverse effects can be increased when Glutethimide is combined with DPDPE.InvestigationalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, IllicitDroperidol may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Drotebanol.Experimental, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Duloxetine.ApprovedThe risk or severity of adverse effects can be increased when Dyclonine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ecgonine.Experimental, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ecopipam.InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Efavirenz.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Eltanolone.InvestigationalThe risk or severity of adverse effects can be increased when Enflurane is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Entacapone.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Escitalopram.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Estazolam is combined with Glutethimide.Approved, IllicitThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Glutethimide.ApprovedGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.ApprovedThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Glutethimide.Approved, Illicit, WithdrawnThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethosuximide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethotoin.ApprovedThe metabolism of Ethyl biscoumacetate can be increased when combined with Glutethimide.WithdrawnThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethyl carbamate.WithdrawnThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethyl chloride.ExperimentalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethyl loflazepate.Approved, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ethylmorphine.Approved, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etidocaine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etifoxine.WithdrawnThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etizolam.ApprovedThe risk or severity of adverse effects can be increased when Etomidate is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etoperidone.WithdrawnThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etorphine.Illicit, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ezogabine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Felbamate.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fencamfamine.Approved, Illicit, WithdrawnThe risk or severity of adverse effects can be increased when Fentanyl is combined with Glutethimide.Approved, Illicit, Investigational, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fexofenadine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Flibanserin.ApprovedFluanisoneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fluanisone.ExperimentalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fludiazepam.Approved, IllicitThe metabolism of Fluindione can be increased when combined with Glutethimide.InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Flunarizine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Flunitrazepam.Approved, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fluoxetine.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Flupentixol is combined with Glutethimide.Approved, WithdrawnThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Flurazepam is combined with Glutethimide.Approved, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fluspirilene.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fluticasone propionate.ApprovedThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Glutethimide.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fosphenytoin.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fospropofol.Approved, IllicitThe risk or severity of adverse effects can be increased when Gabapentin is combined with Glutethimide.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Gabapentin Enacarbil.ApprovedThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Glutethimide.Approved, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Gepirone.InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Guanfacine.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Halazepam is combined with Glutethimide.Approved, Illicit, WithdrawnThe risk or severity of adverse effects can be increased when Haloperidol is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Halothane is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Heroin.Approved, IllicitThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Glutethimide.ApprovedGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, IllicitThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Glutethimide.Approved, IllicitHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Iloperidone.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Imipramine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Indalpine.Investigational, WithdrawnThe risk or severity of adverse effects can be increased when Glutethimide is combined with Indiplon.InvestigationalThe risk or severity of adverse effects can be increased when Isoflurane is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Ketamine is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ketazolam.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ketobemidone.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Lamotrigine.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Levetiracetam.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Levocabastine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Levocetirizine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Levodopa.ApprovedThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Levomilnacipran.ApprovedThe risk or severity of adverse effects can be increased when Levorphanol is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Lidocaine is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Lithium is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Lofentanil.IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Loprazolam.ExperimentalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Loratadine.ApprovedThe risk or severity of adverse effects can be increased when Lorazepam is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Lormetazepam.ApprovedThe risk or severity of adverse effects can be increased when Loxapine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Lurasidone is combined with Glutethimide.ApprovedMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Maprotiline.ApprovedMebicarThe risk or severity of adverse effects can be increased when Glutethimide is combined with Mebicar.ExperimentalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Meclizine.ApprovedMedazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Medazepam.ExperimentalMedetomidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Medetomidine.Vet ApprovedThe risk or severity of adverse effects can be increased when Melatonin is combined with Glutethimide.Approved, Nutraceutical, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Melperone.ApprovedThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Meprobamate is combined with Glutethimide.Approved, IllicitMeptazinolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Meptazinol.ExperimentalThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Metaxalone.ApprovedThe risk or severity of adverse effects can be increased when Methadone is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Glutethimide.Approved, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Methapyrilene.WithdrawnThe risk or severity of adverse effects can be increased when Glutethimide is combined with Methaqualone.Illicit, WithdrawnThe risk or severity of adverse effects can be increased when Glutethimide is combined with Methocarbamol.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Methohexital is combined with Glutethimide.ApprovedGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.ApprovedThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Methsuximide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Methylecgonine.ExperimentalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Glutethimide.ApprovedGlutethimide may increase the sedative activities of Metyrosine.ApprovedThe risk or severity of adverse effects can be increased when Midazolam is combined with Glutethimide.Approved, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Milnacipran.ApprovedMinocycline may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, InvestigationalGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Molindone.ApprovedThe risk or severity of adverse effects can be increased when Morphine is combined with Glutethimide.Approved, InvestigationalNabilone may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Nefazodone.Approved, WithdrawnThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Norflurane.InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Normethadone.Approved, IllicitThe risk or severity of adverse effects can be increased when Glutethimide is combined with Nortriptyline.ApprovedThe risk or severity of adverse effects can be increased when Olanzapine is combined with Glutethimide.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Olopatadine.ApprovedThe risk or severity of adverse effects can be increased when Ondansetron is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Opium.Approved, IllicitGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Osanetant.InvestigationalThe risk or severity of adverse effects can be increased when Oxazepam is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Oxethazaine.InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Oxprenolol.ApprovedThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Oxycodone is combined with Glutethimide.Approved, Illicit, InvestigationalThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Glutethimide.Approved, Investigational, Vet ApprovedThe risk or severity of adverse effects can be increased when Paliperidone is combined with Glutethimide.ApprovedGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Paroxetine.Approved, InvestigationalPenfluridolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Penfluridol.ExperimentalThe risk or severity of adverse effects can be increased when Pentazocine is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Glutethimide.Approved, Vet ApprovedPerampanel may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Perazine.InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Perospirone.ApprovedThe risk or severity of adverse effects can be increased when Perphenazine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Pethidine is combined with Glutethimide.ApprovedPhenazocineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Phenazocine.ExperimentalPhenibutThe risk or severity of adverse effects can be increased when Glutethimide is combined with Phenibut.ExperimentalThe metabolism of Phenindione can be increased when combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Glutethimide.ApprovedPhenoperidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Phenoperidine.ExperimentalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Phenoxyethanol.ApprovedThe metabolism of Phenprocoumon can be increased when combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Phenytoin.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Pimozide is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pipamperone.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pipotiazine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Piritramide.InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pizotifen.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pomalidomide.ApprovedGlutethimide may increase the sedative activities of Pramipexole.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Pramocaine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Prazepam.Approved, IllicitThe risk or severity of adverse effects can be increased when Pregabalin is combined with Glutethimide.Approved, Illicit, InvestigationalThe risk or severity of adverse effects can be increased when Prilocaine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Primidone.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Procaine is combined with Glutethimide.Approved, Investigational, Vet ApprovedThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Promazine is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Promethazine.ApprovedPropanididThe risk or severity of adverse effects can be increased when Glutethimide is combined with Propanidid.ExperimentalThe risk or severity of adverse effects can be increased when Proparacaine is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Propofol is combined with Glutethimide.Approved, Investigational, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Propoxycaine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Protriptyline.ApprovedProxibarbalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Proxibarbal.ExperimentalPSD502The risk or severity of adverse effects can be increased when Glutethimide is combined with PSD502.InvestigationalThe risk or severity of adverse effects can be increased when Quazepam is combined with Glutethimide.Approved, IllicitThe risk or severity of adverse effects can be increased when Quetiapine is combined with Glutethimide.ApprovedQuinisocaineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Quinisocaine.ExperimentalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Raclopride.InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ramelteon.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Remifentanil is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Remoxipride is combined with Glutethimide.Approved, WithdrawnThe risk or severity of adverse effects can be increased when Reserpine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Risperidone is combined with Glutethimide.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ritanserin.InvestigationalRomifidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Romifidine.Vet ApprovedGlutethimide may increase the sedative activities of Ropinirole.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Glutethimide.ApprovedGlutethimide may increase the sedative activities of Rotigotine.ApprovedThe risk or severity of adverse effects can be increased when Rufinamide is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Scopolamine.ApprovedThe risk or severity of adverse effects can be increased when Secobarbital is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Sepranolone.InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Sertindole.Approved, WithdrawnThe risk or severity of adverse effects can be increased when Glutethimide is combined with Sertraline.ApprovedThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Glutethimide.Approved, Vet ApprovedSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Stiripentol.ApprovedThe risk or severity of adverse effects can be increased when Sufentanil is combined with Glutethimide.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Sulpiride is combined with Glutethimide.ApprovedSultoprideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Sultopride.ExperimentalGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tandospirone.InvestigationalTapentadol may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tasimelteon.ApprovedThe risk or severity of adverse effects can be increased when Temazepam is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tetrabenazine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tetracaine.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tetrahydropalmatine.InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tetrodotoxin.InvestigationalGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, WithdrawnThe risk or severity of adverse effects can be increased when Thiamylal is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Thiopental is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Thioridazine is combined with Glutethimide.WithdrawnThe risk or severity of adverse effects can be increased when Thiothixene is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tiagabine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tiapride.Approved, InvestigationalTiletamineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tiletamine.Vet ApprovedTilidineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tilidine.ExperimentalTioclomarolThe metabolism of Tioclomarol can be increased when combined with Glutethimide.ExperimentalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tizanidine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tolcapone.Approved, WithdrawnThe risk or severity of adverse effects can be increased when Glutethimide is combined with Topiramate.ApprovedThe risk or severity of adverse effects can be increased when Tramadol is combined with Glutethimide.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Trans-2-Phenylcyclopropylamine.ExperimentalThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Trazodone is combined with Glutethimide.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Triazolam is combined with Glutethimide.ApprovedTricaine methanesulfonateThe risk or severity of adverse effects can be increased when Glutethimide is combined with Tricaine methanesulfonate.Vet ApprovedTrichloroethyleneThe risk or severity of adverse effects can be increased when Glutethimide is combined with Trichloroethylene.ExperimentalThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Glutethimide.ApprovedTrifluperidolThe risk or severity of adverse effects can be increased when Glutethimide is combined with Trifluperidol.ExperimentalThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Glutethimide.Approved, Vet ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Trimipramine.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Triprolidine.ApprovedThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Glutethimide.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Venlafaxine.ApprovedVeraliprideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Veralipride.ExperimentalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Vigabatrin.ApprovedVinyl etherThe risk or severity of adverse effects can be increased when Glutethimide is combined with Vinyl ether.ExperimentalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Vortioxetine.ApprovedThe metabolism of Warfarin can be increased when combined with Glutethimide.ApprovedXenonThe risk or severity of adverse effects can be increased when Glutethimide is combined with Xenon.ExperimentalXylazineThe risk or severity of adverse effects can be increased when Glutethimide is combined with Xylazine.Vet ApprovedThe risk or severity of adverse effects can be increased when Zaleplon is combined with Glutethimide.Approved, Illicit, InvestigationalThe risk or severity of adverse effects can be increased when Glutethimide is combined with Ziconotide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Zimelidine.WithdrawnThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Glutethimide.ApprovedZolazepamThe risk or severity of adverse effects can be increased when Glutethimide is combined with Zolazepam.Vet ApprovedGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Zonisamide.Approved, InvestigationalThe risk or severity of adverse effects can be increased when Zopiclone is combined with Glutethimide.ApprovedThe risk or severity of adverse effects can be increased when Glutethimide is combined with Zotepine.ApprovedThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Glutethimide.Approved, InvestigationalFood InteractionsAvoid alcohol.
Take without regard to meals.Synthesis ReferenceHoffmann, K. and Tagmann, E.; U.S. Patent 2,673,205; March 23, 1954; assigned to Ciba Pharmaceutical Products, Inc.
General ReferencesNot AvailableExternal LinksHuman Metabolome DatabaseKEGG DrugKEGG CompoundPubChem CompoundPubChem SubstanceChemSpiderChEBIChEMBLTherapeutic Targets DatabasePharmGKBWikipediaATC CodesClinical Trials Not AvailableManufacturersNot AvailablePackagersNot AvailableDosage formsNot AvailablePricesNot AvailablePatentsNot AvailableStateSolidExperimental PropertiesSourcemelting point (°C)78-81Hoffmann, K. and Tagmann, E.; U.S. Patent 2,673,205; March 23, 1954; assigned to Ciba Pharmaceutical Products, Inc.water solubility999 mg/L (at 30 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)logP1.90HANSCH,C ET AL. (1995)logS-2.34ADME Research, USCDpKa9.2SANGSTER (1994)Predicted PropertiesSourceWater Solubility0.327 mg/mLlogP1.89logP2.13logS-2.8pKa (Strongest Acidic)11.69pKa (Strongest Basic)-6.7Physiological Charge0Hydrogen Acceptor Count2Hydrogen Donor Count1Polar Surface Area46.17 ?2Rotatable Bond Count2Refractivity60.65 m3·mol-1Polarizability23.15 ?3Number of Rings2Bioavailability1Rule of FiveYesGhose FilterYesVeber's RuleNoMDDR-like RuleNoPredicted ADMET featuresPropertyValueProbabilityHuman Intestinal Absorption+0.9973Blood Brain Barrier+0.996Caco-2 permeable+0.5931P-glycoprotein substrateSubstrate0.6677P-glycoprotein inhibitor INon-inhibitor0.5334P-glycoprotein inhibitor IINon-inhibitor0.9611Renal organic cation transporterNon-inhibitor0.7747CYP450 2C9 substrateNon-substrate0.7785CYP450 2D6 substrateNon-substrate0.894CYP450 3A4 substrateSubstrate0.5173CYP450 1A2 substrateNon-inhibitor0.8856CYP450 2C9 inhibitorNon-inhibitor0.9101CYP450 2D6 inhibitorNon-inhibitor0.8664CYP450 2C19 inhibitorNon-inhibitor0.8671CYP450 3A4 inhibitorNon-inhibitor0.863CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8527Ames testNon AMES toxic0.8254CarcinogenicityNon-carcinogens0.8911BiodegradationNot ready biodegradable0.9927Rat acute toxicity2.5276 LD50, mol/kg Not applicablehERG inhibition (predictor I)Weak inhibitor0.9778hERG inhibition (predictor II)Non-inhibitor0.7311 ADMET data is predicted using , a free tool for evaluating chemical ADMET properties. () Mass Spec (NIST) (9.43 KB) SpectraSpectrumSpectrum TypePredicted GC-MSNot AvailableGC-MSGC-MSPredicted LC-MS/MSNot AvailablePredicted LC-MS/MSNot AvailablePredicted LC-MS/MSNot AvailablePredicted LC-MS/MSNot AvailablePredicted LC-MS/MSNot AvailablePredicted LC-MS/MSNot AvailableDescriptionThis compound belongs to the class of organic compounds known as phenylpiperidines. These are compounds containing a phenylpiperidine skeleton, which consists of a piperidine bound to a phenyl group.KingdomSuper ClassClassSub ClassDirect ParentAlternative Parents /
/ SubstituentsPhenylpiperidine / Piperidinedione / Delta-lactam / Piperidinone / Monocyclic benzene moiety / Benzenoid / Carboxylic acid imide / Dicarboximide / Carboxylic acid imide, n-unsubstituted / LactamCarboxylic acid derivative / Azacycle / Organic nitrogen compound / Hydrocarbon derivative / Organic oxide / Organopnictogen compound / Organic oxygen compound / Carbonyl group / Organonitrogen compound / Organooxygen compound / Aromatic heteromonocyclic compoundMolecular FrameworkAromatic heteromonocyclic compoundsExternal Descriptorspiperidines () Targets Details1. KindProteinOrganismHumanPharmacological actionYesActionsAgonistGeneral FunctionInhibitory extracellular ligand-gated ion channel activitySpecific FunctionComponent of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine...Gene NameGABRA1Uniprot IDUniprot NameGamma-aminobutyric acid receptor subunit alpha-1Molecular Weight DaReferencesSkerritt JH, Johnston GA: Interactions of some anaesthetic, convulsant, and anticonvulsant drugs at GABA-benzodiazepine receptor-ionophore complexes in rat brain synaptosomal membranes. Neurochem Res. ):1351-62. []
Details2. KindProtein groupOrganismHumanPharmacological actionYesActionsPositive allosteric modulatorGeneral FunctionInhibitory extracellular ligand-gated ion channel activitySpecific FunctionComponent of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine...Components:NameUniProt IDReferencesChEMBL Compound Report Card [] Enzymes Details1. KindProteinOrganismHumanPharmacological actionUnknownActionsInhibitorGeneral FunctionOxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygenSpecific FunctionCatalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.Gene NameCYP11A1Uniprot IDUniprot NameCholesterol side-chain cleavage enzyme, mitochondrialMolecular Weight60101.87 DaReferencesPreissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 J38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. []
Details2. KindProteinOrganismHumanPharmacological actionUnknownActionsInducerGeneral FunctionSteroid hydroxylase activitySpecific FunctionResponsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...Gene NameCYP2D6Uniprot IDUniprot NameCytochrome P450 2D6Molecular Weight55768.94 DaReferencesPearson MW, Roberts CJ: Drug induction of hepatic enzymes in the elderly. Age Ageing. ):313-6. [] Petik D, Acs N, Banhidy F, Czeizel AE: A study of the effects of large doses of glutethimide that were used for self-poisoning during pregnancy on human fetuses. Toxicol Ind Health. 2008 Feb-M24(1-2):69-78. doi: 10.. [] Drug created on July 26,
/ Updated on November 06,
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